VEEV Mouse Model
VEEV MOUSE MODEL
Venezuelan equine encephalomyelitis virus (VEEV) is a mosquito-borne pathogen that can cause acute illness and encephalitis in horses and humans in the Americas. VEEV is considered to be a potential biological weapons agent due to its high infectiousness, ability to incapacitate, and potential for aerosolization and aersol innoculation.
Since there are no vaccines or therapeutics currently approved for the prevention or treatment of VEEV, studies using animal models are important for biodefense and public health programs developing defenses against the virus.
IITRI has recently developed a robust, aerosol-infection VEEV mouse model showing dose-dependent mortality with exposure (see Figure above). The survival curve showed increased mortality with increased dose exposure. The results of this study support the use of the VEE mouse lethal model for vaccine or therapeutic efficacy studies.
Contact us for more information on our VEEV mouse lethal model or GLP compliant Animal Rule studies.