Infectious Disease Efficacy

The demonstration of efficacy in preclinical in vitro assays and animal models is crucial prior to embarking on GLP toxicology studies for IND submissions to conduct first-in-human studies of a new vaccine or antiviral therapeutic. Animal models are also tested when human efficacy studies in humans are not ethical or feasible (FDA Animal Rule). Infectious disease in vitro and in vivo efficacy testing, including GLP-compliant studies, can be conducted in our ABSL-3 animal facility including in vivo models of aerosol infection exposure, and in vitro specialized microbiology and immunology services.

Animal Models

We offer an extensive collection of animal models with a large library of bacterial and viral pathogens for evaluating the efficacy of new vaccines, antibiotics, and antivirals. We also offer pathogen aerosol exposure for nose-only exposure of animals, and have the capability of generating aerosols of powders, liquids and suspensions for delivery of infectious agents or therapeutics by aerosol route. We welcome opportunities for animal model development, please contact us to discuss your infectious disease study.

NEW Animal Models

Disease or Pathogen Species Route
Zika Pregnant Mouse Subcutaneous

VIRAL

Disease or Pathogen Species Route
Zika Pregnant Mouse Subcutaneous
AG129 Mouse Subcutaneous
Rhesus Macaques Subcutaneous
Seasonal Influenza Ferret Intranasal
Mouse Intranasal
Avian Influenza Ferret Intranasal
Mouse Intranasal
RSV Cotton Rat Intranasal
VEEV Mouse Bioaerosol
Marmoset Bioaerosol
Guinea Pig Intraperitoneal
Rabbit Bioaerosol
EEE Guinea Pig Intracerebral
WEE Guinea Pig Intracerebral
Chikungunya Mouse Subcutaneous
Dengue Mouse Subcutaneous
Vaccinia Mouse Subcutaneous

BACTERIAL

Pathogen Disease Species Route
Bacillus anthracis Anthrax Rabbit Bioaerosol
Anthrax Mouse Bioaerosol
Francisella tularensis Tularemia Mouse Bioaerosol
Yersinia pestis Pneumonic Plague Mouse Bioaerosol
Burkholderia pseudomallei Melioidosis Mouse Bioaerosol
Staphylococcus aureus MRSA Mouse Intraperitoneal
Deep puncture thigh wound MRSA Mouse Intramuscular
E. coli O157:H7 Sepsis Mouse Intravenous
Listeria monocytogenes Sepsis Mouse Intravenous
Pseudomonas aeruginosa Bronchiectasis Mouse Bioaerosol

FUNGAL

Disease or Pathogen Species Route
Aspergillus Mouse Intratracheal
Candida albicans Mouse Intravenous
Rat Intravenous

In vitro Efficacy Studies

  • Bacterial Assays
    • MIC Assays
    • Kirby-Bauer Disk Diffusion
  • Viral Assays
    • Plaque Reduction Assays
    • Cytopathic Effect Inhibition Assays
    • Yield Reduction Assays

Contact us to discuss your infectious disease vaccine or therapeutic project.