Carcinogenicity Studies

Studies using animal models to evaluate the carcinogenic potential of pharmaceuticals, although expensive and time-consuming, are a required element of the overall safety assessment of many new drug candidates.

Conventional carcinogenicity studies are 2-year rodent studies, where the animals are followed over a significant portion of their lifespan for the development of neoplastic lesions during or after exposure to the test article. However, there is growing acceptance of newer, 6-month mouse models that use fewer animals and are less costly.

IITRI offers both conventional 2-year and the more economical 6-month study options. Rodent species commonly used for the 2-year studies are Sprague Dawley and Fischer 344 rats and CD-1 mice, and the 6-month studies are typically done in transgenic rasH2 or p53+/- knockout mice.

The IITRI Advantage

  • Highly experienced and tenured scientific staff providing you with a seasoned and stable project team for the duration of your study
  • Technical advisory and support regarding interpretation of study results
  • Board-certified toxicology, pathology, and veterinary staff
  • Over 20 years of experience performing carcinogenicity studies
  • On-site pathology services
  • Access to a large historical control database

Core Services

  • Studies using standard bred mice and rats
  • Studies using transgenic mouse models
  • Studies using inhalation as route of exposure

Contact Us for more information on our carcinogenicity studies.