COVID-19 Syrian hamster model

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covid-19 Syrian hamster model

IITRI has developed a robust model for COVID-19 using the Syrian (golden) hamster. 

Below is a basic study description and design, although IITRI can provide specialized study designs based on your needs. Contact us today to learn more and discuss how we can partner for SARS-CoV-2 animal studies.

 

Species Information Syrian Hamster (~5-6 weeks at challenge)
Study Duration Sponsor dependent (14+ normal)
Challenge Dosage and Strains

Intranasal (25 μl / nare) at  5 x 10^4; wildtype USA-WA1/2020),  B.1.1.7 ,  B.1.35P.1.

Drug administration

Aerosol, PO, IN, SC (inquire about others)

 

Possible Endpoints

– General clinical observations

– Body Weight

– Viral load in nasal washes (TCID50 for live virus, SARS-CoV-2-specific RTqPCR)

– Tissue viral burden by TCID50 and/or RT-qPCR

– Necropsy for histopathology of tissues, to be evaluated with standard H.E. staining

– Neutralizing antibody titer

– Cytokine expression by RT-qPCR