COVID-19 Syrian hamster model
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covid-19 Syrian hamster model
IITRI has developed a robust model for COVID-19 using the Syrian (golden) hamster.
Below is a basic study description and design, although IITRI can provide specialized study designs based on your needs. Contact us today to learn more and discuss how we can partner for SARS-CoV-2 animal studies.
| Species Information | Syrian Hamster (~5-6 weeks at challenge) |
| Study Duration | Sponsor dependent (14+ normal) |
| Challenge Dosage and Strains |
Intranasal (25 μl / nare) at 5 x 10^4; wildtype USA-WA1/2020), B.1.1.7 , B.1.35, P.1.
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| Drug administration |
Aerosol, PO, IN, SC (inquire about others) |
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Possible Endpoints – General clinical observations – Body Weight – Viral load in nasal washes (TCID50 for live virus, SARS-CoV-2-specific RTqPCR) – Tissue viral burden by TCID50 and/or RT-qPCR – Necropsy for histopathology of tissues, to be evaluated with standard H.E. staining – Neutralizing antibody titer – Cytokine expression by RT-qPCR
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Read more about the SARS-CoV-2 Syrian hamster model below:
– Pathogenesis and transmission of SARS-CoV-2 in golden hamsters (Nature article, 05/2020)