COVID-19 transgenic mouse model

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covid-19 transgenic mouse model

IITRI has developed a robust model for COVID-19 using the K18-hACE2 transgenic mouse model.

Below is a basic study description and design, although IITRI can provide specialized study designs based on your needs. Contact us today to learn more and discuss how we can partner for SARS-CoV-2 animal studies.

 

Species Information

K18-hACE2 mice

Study Duration Sponsor dependent (7-14+ typical)
Challenge Dosage and Strains

Intranasal (LD50-LD100); wildtype USA-WA1/2020),  B.1.1.7 ,  B.1.35,  P.1.

Drug administration

Aerosol, PO, IV, IN, SC (inquire about others)

 

Possible Endpoints

– General clinical observations

– Body Weight

– Tissue viral burden by TCID50 and/or RT-qPCR neutralizing antibody titer

– Histopathology of tissues, to be evaluated with standard H.E. staining

– Cytokine expression by RT-qPCR and/or ELISA