COVID-19 transgenic mouse model
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covid-19 transgenic mouse model
IITRI has developed a robust model for COVID-19 using the K18-hACE2 transgenic mouse model.
Below is a basic study description and design, although IITRI can provide specialized study designs based on your needs. Contact us today to learn more and discuss how we can partner for SARS-CoV-2 animal studies.
|Species Information||K18-hACE2 mice|
|Study Duration||Sponsor dependent (7-14+ typical)|
|Challenge Dosage and Strains||
Intranasal (LD50-LD100); wildtype USA-WA1/2020), all relevant variants
|Drug administration||Aerosol, PO, IV, IN, SC (inquire about others)|
– General clinical observations
– Body Weight
– Tissue viral burden by TCID50 and/or RT-qPCR neutralizing antibody titer
– Histopathology of tissues, to be evaluated with standard H.E. staining
– Cytokine expression by RT-qPCR and/or ELISA
Read more about the hACE2 transgenic mouse model below: