COVID-19 transgenic mouse model
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covid-19 transgenic mouse model
IITRI has developed a robust model for COVID-19 using the K18-hACE2 transgenic mouse model.
Below is a basic study description and design, although IITRI can provide specialized study designs based on your needs. Contact us today to learn more and discuss how we can partner for SARS-CoV-2 animal studies.
| Species Information | K18-hACE2 mice |
| Study Duration | Sponsor dependent (7-14+ typical) |
| Challenge Dosage and Strains |
Intranasal (LD50-LD100); wildtype USA-WA1/2020), all relevant variants
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| Drug administration | Aerosol, PO, IV, IN, SC (inquire about others) |
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Possible Endpoints – General clinical observations – Body Weight – Tissue viral burden by TCID50 and/or RT-qPCR neutralizing antibody titer – Histopathology of tissues, to be evaluated with standard H.E. staining – Cytokine expression by RT-qPCR and/or ELISA
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Read more about the hACE2 transgenic mouse model below:
https://www.jax.org/news-and-insights/2020/february/introducing-mouse-model-for-corona-virus
https://www.nature.com/articles/s41586-020-2787-6