Vaccine Toxicology

IITRI has over 15 years of experience conducting vaccine safety and toxicity studies on a variety of vaccine types including inactivated live attenuated viral and bacterial preparations, plasmid DNA, nanoparticles, and viral vector immunotherapies, as well as adjuvanted vaccines. We offer comprehensive GLP vaccine toxicology services including repeat-dose studies in rabbits, rodents and large animals (canine, ferret, and non-human primate/NHPs), biodistribution and immunogenicity studies to meet FDA submission guidelines. We also offer GLP vaccine toxicology studies in BSL-2 for live attenuated viral vaccines against infectious agents or cancer vaccine therapies.

Vaccine Toxicity Studies

Vaccine Toxicology Experience

Study Type Vaccine Animal Model
Toxicity/immunogenicity H5N1 influenza vaccine Rabbits
Toxicity H1N1 influenza vaccine Rabbits
Toxicity Attenuated measles virus Squirrel monkeys
Toxicity Dengue vaccine Immunocompromised mice
Toxicity HPV vaccine Mice
Toxicity Staphylococcus vaccine Rabbits
Toxicity Streptococcus vaccines Rabbits
Toxicity West Nile vaccine Rats
Toxicity Malaria vaccine Rabbits
Toxicity Schistosomiasis vaccines Rats and rabbits
Toxicity Leishmaniasis vaccines Rabbits
Toxicity Filovirus vaccine Rabbits
Immunogenicity Small pox vaccine candidates Immunocompromised mice
Toxicity Plague vaccines Rabbits
Toxicity Tularemia vaccines Rabbits
Toxicity Ricin vaccine Rabbits