Photodynamic Therapy (PDT) Preclinical Studies

IITRI offers preclinical study support for photodynamic therapy (PDT) and light-activated therapeutics, combining pharmaceutical dosing with controlled laser or light exposure to evaluate the safety, tolerability, pharmacology, and therapeutic effects of photosensitizing agents.

Our team has hands-on experience conducting in vivo photodynamic studies (PDT) and has established the specialized equipment and procedures required for controlled light delivery in laboratory animals. This capability enables IITRI to support developers of emerging photosensitizers and other light-activated therapeutics from early proof-of-concept studies through IND-enabling development.

Preclinical PDT Capabilities

IITRI can support studies involving:

• Photosensitizer and light-activated drug evaluation
• In vivo photodynamic therapy (PDT) studies
• Dose-response and light-dose response studies
• Evaluation of local and systemic toxicity
• Phototoxicity and photosensitivity assessment
• Histopathologic evaluation of treatment-related tissue effects
• Pharmacokinetic and toxicokinetic assessments
• GLP and non-GLP PDT preclinical studies

Controlled Light Delivery

PDT studies require precise coordination of drug administration and light exposure. IITRI’s established capability allows investigators to control critical treatment parameters..
Our approach can be adapted to different photosensitizers, therapeutic targets, animal models and routes of administration, allowing sponsors to investigate the relationship between drug exposure and light activation.

Integrated Preclinical Development

As a full-service preclinical research organization, IITRI can integrate photodynamic therapy (PDT) studies with toxicology, pharmacokinetics/toxicokinetics, bioanalysis, histopathology, safety pharmacology and other IND-enabling and NDA studies. This integrated approach can help sponsors efficiently characterize both the drug and the effects of its subsequent light activation.
Whether evaluating a novel photosensitizer, optimizing a PDT treatment regimen or advancing a light-activated therapeutic toward the clinic, IITRI provides the specialized expertise and infrastructure to support your preclinical development program.
Please contact us to discuss or answer any questions you may have about our experience with photodynamic therapy (PDT) studies.