Infectious Disease Animal Models
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Infectious Disease Animal Models
The demonstration of efficacy in preclinical in vitro assays and infectious disease animal models is crucial prior to embarking on GLP toxicology studies of a new vaccine or antiviral therapeutic. Animal models are also tested when human efficacy studies in humans are not ethical or feasible (FDA Animal Rule). Infectious disease in vitro and in vivo challenge studies can be conducted in our ABSL-3 animal facility including in vivo models of aerosol infection exposure, and in vitro microbiology and immunology assay services.
Animal Models by Pathogen
We offer an extensive collection of infectious disease animal models with a large library of bacterial and viral pathogens (including CDC select agents) for development of new vaccines, antibiotics, and antivirals. We also offer pathogen aerosol exposure for nose-only exposure of animals, and have the capability of generating aerosols of powders, liquids and suspensions for delivery of infectious agents or therapeutics by aerosol route.
Abbreviations: IC, intracerebral; IN, intranasal; IM, intramuscular; IP, intraperitoneal; IV, intravenous; SQ, subcutaneous.
VIRAL
Disease or Pathogen | Species | Route |
Avian Influenza (high path) |
Ferret Mouse |
IN IN |
Chikungunya | Mouse | SQ |
Dengue |
Mouse NHP |
SQ SQ |
EEE (Eastern equine encephalitis) |
Mouse Guinea Pig |
IN, IC IN, IC |
Influenza (seasonal) |
Ferret Mouse |
IN IN |
1918 pandemic influenza virus1 |
Ferret Mouse |
IN IN |
RSV | Cotton Rat | IN |
SARS-associated coronavirus (SARS-CoV-1) |
Mouse Guinea Pig |
IN, IC IN, IC |
SARS-associated coronavirus 2 (SARS-CoV-2) |
Mouse Syrian Hamster Ferret |
IN IN IN |
Orthopox (Vaccinia, Monkeypox, Cowpox) |
Mouse NHP |
IN, IV, SC, aerosol IN, IV, SC, aerosol |
VEE (Venezuelan equine encephalitis) |
Mouse Guinea Pig |
IN, IC IN, IC |
WEE (Western equine encephalitis) | Guinea Pig | IC |
Yellow fever | Mouse | SQ |
Zika (Pregnancy Model) | Mouse | SQ |
Zika |
Mouse NHP |
SQ SQ |
1Reconstructed replication competent forms
BACTERIAL
Disease or Pathogen | Species | Route |
Bacillus anthracis |
Rabbit Mouse |
Aerosol Aerosol |
Botulinum neurotoxin producing species of Clostridium |
Mouse Rat |
IP, IV IP,IV |
Brucella abortus | Mouse | IN, IP, SC, aerosol |
Brucella melitensis | Mouse | IN, IP, SC, aerosol |
Brucella suis | Mouse | IN, IP, SC, aerosol |
Burkholderia mallei | Mouse | IN, IP, SC, aerosol |
Burkholderia pseudomallei | Mouse | IN, IP, SC, aerosol |
Coxilla burnetii |
Mouse Rat |
IV, IP IV, IP |
Escherichia coli O157:H7 | Mouse | IV |
Listeria monocytogenes | Mouse | IV |
Francisella tularensis | Mouse | IN, IP, SC, aerosol |
Pseudomonas aeruginosa | Mouse | Aerosol |
Rickettsia prowazekii | Mouse | IV, IP |
Staphylococcus aureus (MRSA) | Mouse | IP |
Yersinia pestis | Mouse | IN, IP, SC, aerosol |
Deep puncture thigh wound (MRSA) | Mouse | IM |
FUNGAL
Disease or Pathogen | Species | Route |
Candida albicans |
Mouse Rat |
IV IV |
Aspergillus |
Mouse Rat |
Aerosol (intratracheal) Aerosol (intratracheal) |
TOXINS
Disease or Pathogen | Species | Route |
Abrin |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Botulinum neurotoxin |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Conotoxins |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Diacetoxyscirpenol |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Ricin |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Staphylococcal enterotoxins A, B (SEB), C, D, E subtypes | Mouse | Aerosol |
T-2 toxin |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Tetrodotoxin |
Mouse Rat |
IN, IP, IV, SQ, aerosol IN, IP, IV, SQ, aerosol |
Download Infectious Disease Animal Model Brochure
