Infectious Disease Animal Models

The demonstration of efficacy in preclinical in vitro assays and infectious disease animal models is crucial prior to embarking on GLP toxicology studies of a new vaccine or antiviral therapeutic. Animal models are also tested when human efficacy studies in humans are not ethical or feasible (FDA Animal Rule). Infectious disease in vitro and in vivo challenge studies can be conducted in our ABSL-3 animal facility including in vivo models of aerosol infection exposure, and in vitro microbiology and immunology assay services.

Animal Models by Pathogen

We offer an extensive collection of infectious disease animal models with a large library of bacterial and viral pathogens (including CDC select agents) for development of new vaccines, antibiotics, and antivirals. We also offer pathogen aerosol exposure for nose-only exposure of animals, and have the capability of generating aerosols of powders, liquids and suspensions for delivery of infectious agents or therapeutics by aerosol route.

Abbreviations: IC, intracerebral; IN, intranasal; IM, intramuscular; IP, intraperitoneal; IV, intravenous; SQ, subcutaneous.

VIRAL

¹Reconstructed replication competent forms

BACTERIAL

FUNGAL

TOXINS