Infectious Disease Animal Models

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Infectious Disease Animal Models

 

The demonstration of efficacy in preclinical in vitro assays and infectious disease animal models is crucial prior to embarking on GLP toxicology studies of a new vaccine or antiviral therapeutic. Animal models are also tested when human efficacy studies in humans are not ethical or feasible (FDA Animal Rule). Infectious disease in vitro and in vivo challenge studies can be conducted in our ABSL-3 animal facility including in vivo models of aerosol infection exposure, and in vitro microbiology and immunology assay services.

 

Animal Models by Pathogen

We offer an extensive collection of infectious disease animal models with a large library of bacterial and viral pathogens (including CDC select agents) for development of new vaccines, antibiotics, and antivirals. We also offer pathogen aerosol exposure for nose-only exposure of animals, and have the capability of generating aerosols of powders, liquids and suspensions for delivery of infectious agents or therapeutics by aerosol route.

Abbreviations: IC, intracerebral; IN, intranasal; IM, intramuscular; IP, intraperitoneal; IV, intravenous; SQ, subcutaneous.

 

VIRAL

Disease or Pathogen Species Route
Avian Influenza (high path) Ferret IN
  Mouse IN
Chikungunya Mouse SQ
Dengue Mouse SQ
  NHP SQ
EEE (Eastern equine encephalitis) Mouse IN, IC
  Guinea Pig IN, IC
Influenza (seasonal) Ferret IN
  Mouse IN
1918 pandemic influenza virus1 Ferret IN
  Mouse IN
RSV Cotton rat IN
SARS-associated coronavirus (SARS-CoV) Mouse IN, IC
  Guinea pig IN, IC
Vaccinia Mouse SQ
VEE (Venezuelan equine encephalitis) Mouse IN, IC
  Guinea Pig IN, IC
WEE (Western equine encephalitis) Guinea Pig IC
Yellow fever Mouse SQ
Zika (Pregnancy Model) Mouse SQ
Zika Mouse SQ
  NHP SQ

1Reconstructed replication competent forms

 

BACTERIAL

Disease or Pathogen Species Route
Bacillus anthracis Rabbit Aerosol
  Mouse Aerosol
Botulinum neurotoxin producing species of Clostridium Mouse IP, IV
  Rat IP, IV
Brucella abortus Mouse IN, IP, SC, aerosol
Brucella melitensis Mouse IN, IP, SC, aerosol
Brucella suis Mouse IN, IP, SC, aerosol
Burkholderia mallei Mouse IN, IP, SC, aerosol
Burkholderia pseudomallei Mouse IN, IP, SC, aerosol
Coxilla burnetii Mouse IV, IP
  Rat IP, IV
Escherichia coli O157:H7 Mouse IV
Listeria monocytogenes Mouse IV
Francisella tularensis Mouse IN, IP, SC, aerosol
Pseudomonas aeruginosa Mouse aerosol
Rickettsia prowazekii Mouse IP, IV
  Rat IP, IV
Staphylococcus aureus (MRSA) Mouse IP
Yersinia pestis Mouse IN, IP, SC, aerosol
Deep puncture thigh wound (MRSA) Mouse IM

 

FUNGAL

Disease or Pathogen Species Route
Candida albicans Mouse IV
  Rat IV
Aspergillus Mouse aerosol (intratracheal)
  Rat aerosol (intratracheal)

 

TOXINS

Disease or Pathogen Species Route
Abrin Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol
Botulinum neurotoxin Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol
Conotoxins Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol
Diacetoxyscirpenol Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol
Ricin Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol
Staphylococcal enterotoxins A, B (SEB), C, D, E subtypes Mouse aerosol
T-2 toxin Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol
Tetrodotoxin Mouse IN, IP, IV, SQ, aerosol
  Rat IN, IP, IV, SQ, aerosol