exposure atmosphere generation
Services
We are ready to answer your questions and provide guidance.
exposure atmosphere generation
Services
We are ready to answer your questions and provide guidance.
exposure atmosphere generation and characterization
Test Article Aerosol Generation Methods
The development of methods for exposure atmosphere generation with a particle size range allowing lung deposition is the first step in any inhalation toxicology study. Preliminary method development activities can include:
- Development and optimization of methods to generate the test atmosphere, including a determination of the Maximum Feasible Concentration (MFC).
- Characterization of test atmosphere, including test article concentration; particle size distribution (Mass Median Aerodynamic Diameter and Geometric Standard Deviation), spatial uniformity and temporal stability evaluations that encompass the maximum intended duration of in vivo exposure. Note: Exposure characterization is limited to gravimetric filter if the study needs to be conducted in an ABSL3. Collection of impinger samples and chemical analysis can also be performed.
- Technology transfer of the method for quantitative analysis of test article in exposure system filters (HPLC; to permit characterization of exposure levels)
Our expert staff has decades of experience working with a wide range of chemicals and drugs with complex properties, including:
- Gasses or vapors
- Liquids and suspensions
- Powders, fibers or nanoparticles
- Metered dose inhaler formulations and devices
- Electronic cigarettes or tobacco product smoke
The IITRI Advantage
- Over 40 years of expertise in aerosol science and inhalation exposure study teams including PhD aerosol scientists and DABT toxicologists
- Comprehensive preclinical testing programs available to support IND and NDA submissions for drugs utilizing inhalation drug delivery
- Experience handling difficult materials including solids, liquids, and gasses
