Inhalation Toxicology

IITRI is a premier provider of inhalation toxicology services to the pharmaceutical, biotechnology, chemical, agrochemical, and consumer products industries. We have over 40 years of experience in the evaluation of potential inhaled therapeutics for respiratory diseases such as asthma, COPD and pulmonary fibrosis, and in evaluating the toxicity of chemicals, metals and pesticides as potential environmental or occupational hazards. Occupational toxicology and nonclinical studies are conducted in all relevant animal models and in accordance with testing guidelines of the FDA, EPA, OECD and other regulatory agencies. We have also conducted large studies for the inhalation toxicology testing of cigarette smoke, electronic cigarettes and flavors (Ecigs) and tobacco products.

Study Types

IITRI offers comprehensive preclinical testing programs available to support GLP-compliant IND and NDA submissions for pharmaceuticals utilizing inhalation as a route of administration. We also offer high-containment GLP-compliant Biosafety Level (BSL) 2/3+ infectious disease inhalation studies.

Methods of Inhalation Exposure

Our laboratories are well equipped with inhalation chambers and monitoring systems to perform various types of inhalation exposures on mice, rats, rabbits, canines and non-human primates (NHPs), including:

Test Atmosphere Development

Our staff has decades of experience in inhalation science developing methods for atmosphere generation of a wide range of chemicals and drugs with complex properties, including:

  • Gas or vapors
  • Liquids and suspensions
  • Powders, fibers or nanoparticles
  • Metered dose inhaler formulations
  • Electronic cigarettes (Ecigs)
  • Smoke (tobacco products)

The IITRI Advantage

  • Expertise in aerosol science and inhalation exposure—our team includes PhD aerosol scientists in addition to DABT toxicologists
  • Comprehensive preclinical testing programs available to support IND and NDA submissions for drugs utilizing inhalation as a route of administration
  • Personalized program design to meet your specific needs including non-standard and customized studies
  • On-site bioanalytical laboratory to support GLP requirements for toxicology studies