Peer-Reviewed Journal Publications

Newly Published!

Pleus RC, Bruce G, Klintworth H, Sullivan D, Johnson W, Rajendran N, and Keenan J. Repeated dose inhalation developmental toxicity study in rats exposed to cellulose insulation with boric acid additive. Inhal Toxicol. 2019:1-11. Epub 2019/03/04.

Eiden J, Gordon G, Fierro C, Belshe R, Greenberg H, Hoft D, Hatta Y, Imboden M, Moser M, Herber R, Boltz D, et al. 1970. Phase 1 Clinical Trial of Intranasal Immunization with M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR): Safety and Immune Response in Adults. Open Forum Infectious Diseases. 2018;5(suppl_1):S571-S2.

Hatta Y, Boltz D, et al. Novel influenza vaccine M2SR protects against drifted H1N1 and H3N2 influenza virus challenge in ferrets with pre-existing immunity. Vaccine. 2018;36(33):5097-103. Epub 2018/07/13.

Toxicology and Inhalation Toxicology

Pleus RC, Bruce G, Klintworth H, Sullivan D, Johnson W, Rajendran N, and Keenan J. Repeated dose inhalation developmental toxicity study in rats exposed to cellulose insulation with boric acid additive. Inhal Toxicol. 2019:1-11. Epub 2019/03/04.

Moore L, Yang J, Lan TTH, Osawa E, Lee D-K, Johnson WD, et al. 2016. Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis. ACS Nano.10(8):7385-400.

Manjanatha MG, Shelton SD, Haber L, Gollapudi B, MacGregor JA, Rajendran N, Moore MM. 2015. Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks. Mutat Res Genet Toxicol Environ Mutagen 789-790:46-52.

Eldridge SR, Covey J, Morris J, Fang B, Horn TL, Elsass KE, Hamre JR 3rd, McCormick DL, Davis MA. 2014. Characterization of acute biliary hyperplasia in Fisher 344 Rats administered the Indole-3-Carbinol Analog, NSC-743380. Toxicol Appl Pharmacol 281(3):303-9.

Rajendran N, Hu SC, Sullivan D, Muzzio M et al. 2012. Toxicologic evaluation of tungsten: 28-day inhalation study of tungsten blue oxide in rats. Inhal Toxicol 24(14):985-94.

Repacholi MH, Lerchl A, Roosli M, Sienkiewicz Z, Auvinen A, Breckenkamp J, d'Inzeo G, Elliott P, Frei P, Heinrich S, Lagroye I, Lahkola A, McCormick DL, Thomas S, Vecchia, Pl. 2012.Systematic review of wireless phone use and brain cancer and other head tumors. Bioelectromagnetics 33(3):187-206.

Johnson WD, Morrissey RL, Usborne AL, Kapetanovic I, Crowell JA,Muzzio M, McCormick DL. 2011. Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity. Food Chem Toxicol 49(12):3319-27.

Johnson WD, Muzzio M, Detrisac CJ, Kapetanovic IM, Kopelovich L, McCormick DL. 2011. Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs. Toxicology 289(2-3):141-50.

Kapetanovic IM, Horn TL, Johnson WD, Cwik MJ, Detrisac CJ, McCormick DL. 2010. Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention. Int J Toxicol 29(2):157-64. J Pharm Biomed Anal 52(4):544-9.

Analytical Chemistry and Pharmacokinetics

Lee O, Muzzio M, et al. Abstract OT3-02-09: 2017. Abstract OT3-02-09: Phase II pre-surgical window trial of telapristone acetate (TPA) in early breast cancer and DCIS patients: Distribution of TPA in plasma, normal breast tissue and tumors. Cancer Research 77 (4 Supplement):OT3-02-09-OT3-02-09. doi: 10.1158/1538-7445.sabcs16-ot3-02-09.3.

Sahadevan M, Lee O, Muzzio M et al. The relationship of single strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens. Biomarkers. 2017:1-31.

Holleran JL, Beumer JH, McCormick DL, Johnson WD et al. 2015. Oral and intravenous pharmacokinetics of 5-fluoro-2'-deoxycytidine and THU in cynomolgus monkeys and humans. Cancer Chemother Pharmacol 76(4):803-11.

Chatterton RT, Muzzio M, Heinz R, Gann PH, Khan SA. 2015. Methodological considerations in estrogen assays of breast fluid and breast tissue. Steroids 99(Pt. A):103-107.

Muzzio M, Hu SC, Holleran JL, Parise RA, Eiseman JL, Yellow-Duke AE, Covey JM, Glaze ER, Engelke K, Egorin MJ, McCormick DL, Beumer JH. 2015. Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs. Cancer Chemother Pharmacol 75(5):1015-23.

Chatterton RT, Muzzio M, Gann PH. 2014. Concerns about methods for determination of estrogens in body fluids.. Breast Cancer Res Treat 148(3):685.

Krstenansky JL, Muzzio M. 2014. Analysis of the smoke of cigarettes containing Salvia divinorum. J Anal Toxicol 38(7):451-5.

Kapetanovic IM, Muzzio M, McCormick DL, Thompson TN, Johnson WD, Horn TL et al. 2012. Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats. Cancer Chemother Pharmacol 69(5):1301-6.

Muzzio M, Huang Z, Hu SC, Johnson WD, McCormick DL, Kapetanovic IM. 2012. Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs. J Pharm Biomed Anal 59:201-8.

Muzzio M, Huang Z, Johnson WD, McCormick DL, Kapetanovic IM. 2011. Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS. J Pharm Biomed Anal 56(4):809-14.

Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL. 2011. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol 68(3):593-601.

Jia L, Gorman GS, Coward LU, Noker PE, McCormick D, Horn TL, Harder JB, Muzzio M et al. 2011. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol 68(2):513-24.

Cwik MJ, Wu H, Muzzio M, McCormick DL, Kapetanovic I. 2010. Direct quantitation of glucoraphanin in dog and rat plasma by LC-MS/MS. J Pharm Biomed Anal 52(4):544-9.

Kapetanovic IM, Muzzio M, Hu SC, Crowell JA, Rajewski RA, Haslam JL, Jong L, McCormick DL. 2010. Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. Cancer Chemother Pharmacol 65(6):1109-16.

Cancer Chemoprovention and Chemotherapy

Thompson MD, Lubet RA, McCormick DL, et al. Lack of chemopreventive efficacy of metformin in rodent models of urinary bladder, head and neck, and colon/intestine cancer. Oncology Letters. 2017(14):3480-6. doi: 10.3892/ol.2017.6632.

Gong Y, Capstick MH, Kuehn S, Wilson PF, Ladbury JM, Koepke G, McCormick DL, et al. 2017. Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation. IEEE Transactions on Electromagnetic Compatibility PP (99):1-11. doi: 10.1109/TEMC.2017.2665039.

Capstick MH, Kuehn S, Berdinas-Torres V, Gong Y, Wilson PF, Ladbury JM, Koepke G, McCormick DL, Gauger J, Melnick RL, and Kuster N. 2017. A Radio Frequency Radiation Exposure System for Rodents Based on Reverberation Chambers. IEEE Transactions on Electromagnetic Compatibility 59 (4):1041-1052. doi: 10.

Alimirah F, Peng X, Gupta A, Yuan L, Welsh J, Cleary M, and Mehta RG. 2016. Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells. Exp Cell Res 349 (1):15-22. doi: 10.1016/j.yexcr.2016.08.012.

Lubet RA, Townsend R, Clapper ML, Juliana MM, Steele VE, McCormick DL, et al. 2016. 5MeCDDO Blocks Metabolic Activation but not Progression of Breast, Intestine, and Tongue Cancers. Is Antioxidant Response Element a Prevention Target? Cancer Prev Res (Phila). Jul;9(7):616-23.

McCormick DL, Horn TL, Johnson WD, Peng X, Lubet RA, Steele VE. 2015. Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor gamma. PLoS One 10(10):e0141849.

Lee O, Ivancic D, Allu S, Shidfar A, Kenney K, Helenowski I, Sullivan ME, Muzzio M, Scholtens D, Chatterton RT Jr, Bethke KP, Hansen NM, Khan SA. 2015. Local transdermal therapy to the breast for breast cancer prevention and DCIS therapy: preclinical and clinical evaluation. Cancer Chemother Pharmacol 76(6):1235-46.

Lee O, Page K, Ivancic D, Helenowski I, Parini V, Sullivan ME, Margenthaler JA, Chatterton RT, Jr., Jovanovic B, Dunn BK, Heckman-Stoddard BM, Foster K, Muzzio M et al. 2014. A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast. Clin Cancer Res 20(14):3672-82.

Peng X, Li W, Yuan L, Mehta RG, Kopelovich L, McCormick DL. 2013. Inhibition of proliferation and induction of autophagy by Atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21. PLoS One 8(8):e70442.

Mehta R, Katta H, Alimirah F, Patel R, Murillo G, Peng X, Muzzio M, Mehta RG. 2013. Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells. PLoS One 8(6):e65113.

Mehta RR, Katta H, Kalra A, Patel R, Gupta A, Alimirah F, Murillo G, Peng X, Unni A, Muzzio M, Mehta RG. 2013. Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells. Clin Exp Metastasis 30(7):855-66.

Mehta RG, Peng X, Roy S, Hawthorne M, Kalra A, Alimirah F, Mehta RR, Kopelovich L. 2013. PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance. Mol Cell Biochem 372:249-56

Gupta A, Mehta R, Alimirah F, Peng X, Murillo G, Wiehle R, Mehta RG. 2013. Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells. J Steroid Biochem Mol Biol 133:30-42.

Mehta RG, Peng X, Alimirah F, Murillo G, Mehta R. 2013. Vitamin D and breast cancer: Emerging concepts. Cancer Lett 334(1):95-100.

Alimirah F, Peng X, Yuan L, Mehta RR, von Knethen A, Choubey D, Mehta RG. 2012. Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D3 mediated transactivation. Exp Cell Res 318(19):2490-7.

Peng X, Tiwari N, Roy S, Yuan L, Murillo G, Mehta RR, Benya RV, Mehta RG. 2012. Regulation of CYP24 splicing by 1,25-dihydroxyvitamin D3 in human colon cancer cells. J Endocrinol 212(2):207-15.

Lubet RA, Clapper ML, McCormick DL et al. 2012. Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers. Oncol Rep 27(5):1400-6.

Mehta RR, Hawthorne M, Peng X, Shilkaitis A, Mehta RG et al. 2010. A 28-amino-acid peptide fragment of the cupredoxin azurin prevents carcinogen-induced mouse mammary lesions. Cancer Prev Res (Phila) 3(10):1351-60.

Peng X, Vaishnav A, Murillo G, Alimirah F, Torres KE, Mehta RG. 2010. Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells. J Cell Biochem 110(6):1324-33.

Mehta RG, Murillo G, Naithani R, Peng X. 2010. Cancer chemoprevention by natural products: how far have we come? Pharm Res 27(6):950-61.

Mooso B, Madhav A, Johnson S, Roy M, Moore ME, Moy C, Loredo GA, Mehta RG et al. 2010. Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α-Hydroxyvitamin D5 - a calcitriol analog. Genes Cancer 1(9):927-940.

Alimirah F, Vaishnav A, McCormick M, Echchgadda I, Chatterjee B, Mehta RG, Peng X. 2010. Functionality of unliganded VDR in breast cancer cells: repressive action on CYP24 basal transcription. Mol Cell Biochem 342(1-2):143-50.

Murillo G, Nagpal V, Tiwari N Benya RV, Mehta RG. 2010. Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer. J Steroid Biochem Mol Biol 121(1-2):403-7.

Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene 29(2):285-96.

McCormick DL, Rao KV, Johnson WD et al. 2010. Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate. Cancer Prev Res (Phila) 3(3):381-92.

McCormick DL, Phillips JM, Horn TL, Johnson WD et al. 2010. Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. Cancer Prev Res (Phila) 3(1):73-81.

Cancer Biology

Peng X, McCormick DL. 2016. Identification of reliable reference genes for quantitative gene expression studies in oral squamous cell carcinomas compared to adjacent normal tissues in the F344 rat model. Oncology Reports 36(2):1076-84. doi: 10.3892/or.2016.4883.

Peng X, Li W, Johnson WD, Torres KE, McCormick DL. 2015. Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. PLoS One 10(1):e0116285.

Mehta RG, Hawthorne M, Mehta RR, Torres KE, Peng X, McCormick DL, Kopelovich L. 2014. Differential roles of ER alpha and ER beta in normal and neoplastic development in the mouse mammary gland. PLoS One 9(11):e113175.

Saleiro D, Murillo G, Benya RV, Bissonnette M, Hart J, Mehta RG. 2012. Estrogen receptor-β protects against colitis-associated neoplasia in mice. Int J Cancer 131(11):2553-61.

Alimirah F, Peng X, Murillo G, Mehta RG. 2011. Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS One 6(1):e16024.

Mackinnon AC, Tretiakova M, Henderson L,Mehta RG et al. 2011. Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol 64(1):16-24.

Saleiro D, Murillo G, Lubahn DB, Kopelovich L, Korach KS, Mehta RG. 2010. Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice. Cancer Prev Res (Phila) 3(9):1198-204.

Infectious Disease

Hatta Y, Boltz D, et al. Novel influenza vaccine M2SR protects against drifted H1N1 and H3N2 influenza virus challenge in ferrets with pre-existing immunity. Vaccine. 2018;36(33):5097-103. Epub 2018/07/13.

Richner JM, Jagger BW, Shan C, Fontes CR, et al. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease. Cell.170(2):273-83.e12.

Hatta Y, Boltz D, Sarawar S, Kawaoka Y, Neumann G, Bilsel P. M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza. Vaccine. 2017. Epub ahead of print 2017/06/28.

Grossman TH, Anderson MS, Christ D, Gooldy M, Henning LN, Heine HS, Kindt MV, Lin W. et al. The fluorocycline TP-271 is efficacious in models of aerosolized Francisella tularensis SCHU S4 infection in BALB/c mice and cynomolgus macaques. Antimicrob Agents Chemother. 2017.

Boltz D, Curry P and Baker R. Development of models for Zika virus infection in mice and Rhesus macaques using a contemporary virus strain. International Journal of Infectious Diseases , 53S (2016) 4–163.

Shiratori I, Akitomi J,Boltz DA et al. 2014. Selection of DNA aptamers that bind to influenza A viruses with high affinity and broad subtype specificity. Biochem Biophys Res Commun 443(1):37-41.

Bayne AC, Boltz D et al. 2013. Vaccination against influenza with recombinant hemagglutinin expressed by Schizochytrium sp. confers protective immunity. PLoS One 8(4):e61790.

Fellows P, Lin W, Detrisac C, Hu SC, Rajendran N, Gingras B, Holland L et al. 2012. Establishment of a Swiss Webster mouse model of pneumonic plague to meet essential data elements under the animal rule. Clin Vaccine Immunol 19(4):468-76.

Castillo R, Holland LE, Boltz DA. 2010. Peramivir and its use in H1N1 influenza. Drugs Today (Barc) 46(6):399-408.

Sagripanti JL, Rom AM, Holland LE. 2010. Persistence in darkness of virulent alphaviruses, Ebola virus, and Lassa virus deposited on solid surfaces. Arch Virol 155(12):2035-9.

Fellows P, Adamovicz J, Hartings J, Sherwood R, Mega W, Brasel T, Barr E, Holland L, Lin W, Rom A et al. 2010. Protection in mice passively immunized with serum from cynomologus macaques and humans vaccinated with recombinant plaque vaccine (rF1V). Vaccine 28(49):7748-56.

Other Topics

Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, et al. 2017. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1620717114

Kannas CC, Kalvari I, Lambrinidis G, Neophytou CM, Savva CG, Kirmitzoglou I, Antoniou Z, Achilleos KG, Scherf D, Pitta CA, Nicolaou, C. A, Mikros E, Promponas VJ, Gerhauser C, Mehta RG et al. 2015. LiSIs: An Online Scientific Workflow System for Virtual Screening. Comb Chem High Throughput Screen 18(3):281-95.

Wren MA, Dauchy RT, Hanifin JP, Jablonski MR, Warfield B, Brainard GC, Blask DE, Hill SM, Ooms TG, Bohm RP, Jr. 2014. Effect of different spectral transmittances through tinted animal cages on circadian metabolism and physiology in Sprague-Dawley rats. J Am Assoc Lab Anim Sci 53(1):44-51.

Swarup VP, Huang Y, Murillo G, Saleiro D, Mehta RG, Bishnoi SW. 2011. Modeling the cellular impact of nanoshell-based biosensors using mouse alveolar macrophage cultures. Metallomics 3(11):1218-26.

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