Posters, White Papers, and Case Studies

White Papers

API Sparing Techniques for Inhalation Toxicology Studies
R. Narayanan and P. Ahrweiler

Inhalation toxicology studies often require large quantities of drug substance. However, available API may be limited by expensive or difficult manufacturing. Learn how to conserve API in early preclinical inhalation PK studies with these API-sparing inhalation dosing techniques.

Case Studies

Generating a Test Atmosphere with a Difficult-to-aerosolize Material
P. Ahrweiler and R. Pleus

The first step in conducting inhalation toxicology studies is the generation of a reliable and consistent test atmosphere of the aerosolized drug, chemical or substance. Read how IITRI was selected by a toxicology consultant sponsor to turn their solid building material, cellulose insulation, into a respirable particle size powder to conduct an inhalation developmental and reproductive (DART) toxicology study and ensure the safety of workers handling this material.

Posters

Combined Fertility and Embryofetal Developmental Toxicity Study of Cytisine in Rats
2019 Society of Toxicology 58th Annual Meeting, Baltimore, MD

Phase 1 Clinical Trial of Intranasal Immunization with M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR): Safety and Immune Response in Adults
IDWeek 2018, San Francisco, CA

Six Month Oral Toxicity Study of (E/Z)-Endoxifen in Rats
AACR Annual Meeting 2018, Chicago, IL

Enhanced Oral Bioavailability of 3,3’-Diindolylmethane Administered in a Self-Microemulsifying Drug Delivery System (SMEDDS)
AACR Annual Meeting 2018, Chicago, IL

Interspecies Comparison of In Vitro Endoxifen Metabolism
AACR Annual Meeting 2018, Chicago, IL

Safety Assessment of (E/Z)-Endoxifen and (E/Z)-Endoxifen Gel in Toxicology Screening Assays
2018 Society of Toxicology 57th Annual Meeting, San Antonio, TX

Repeat-Dose Toxicity and Metabolism of Topical (E/Z)-Endoxifen Gel in Minipigs
2018 Society of Toxicology 57th Annual Meeting, San Antonio, TX

Immunogenicity and Safety Assessment of Hantaan and Puumala Virus DNA Vaccines in Rabbits
2018 Society of Toxicology 57th Annual Meeting, San Antonio, TX

Humoral and Cellular Immune Dynamics following Zika Virus Secondary Challenge in Non-Human Primates
2018 ASM Biothreats, Baltimore, MD

Influenza A Exposure Exacerbates Pneumonic Plague Infection in Swiss Webster Mice
Options IX for the Control of Influenza 2016, Chicago, IL

Development of an Aerosol Delivery System for Multiple Simultaneous Exposures of Rabbits to Aerosolized Bacillus anthracis
ASM Biodefense and Emerging Diseases 2016, Arlington, VA

Development of a Murine Bacillus anthracis Treatment Model Using a 21 day Ciprofloxacin and Doxycycline Dosing Schedule
ASM Biodefense and Emerging Diseases 2015, Washington, DC

Antiviral Activity of Enisamium Against Influenza Viruses in Differentiated Normal Human Bronchial Epithelial Cells
3rd Antivirals Congress 2014, Amsterdam, The Netherlands

Comparative Pharmacokinetics of the Polyphenol, Pterostilbene, in Rhesus Macaques, Cynomolgus Macaques, and Common Marmosets
Society of Toxicology 53rd Annual Meeting 2014, Phoenix, AZ

Repeat Dose Rabbit Vaginal Tolerance/ Toxicity Study of Diindolylmethane Cream for Topical Treatment of Cervical Intraepithelial Neoplasia
Society of Toxicology 53rd Annual Meeting 2014, Phoenix, AZ

Development of Francisella tularensis Schu S4 Post-exposure Prophylaxis and Delayed Treatment Models
ASM Biodefense and Emerging Diseases 2014, Washington, DC

Development of Yersinia pestis CO92 Aerosol Post-exposure Prophylaxis and Delayed Treatment Models
ASM Biodefense and Emerging Diseases 2014, Washington, DC

An Automated Microneutralization Plaque Assay to Measure Serum Antibodies against Influenza A Virus H1, H5 and H7 Subtypes
Infectious Diseases World Summit 2013, Boston, MA