COVID-19 ferret model

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covid-19 Ferret model

IITRI offers a ferret model for COVID-19 which is a robust choice for studies focused on upper respiratory effects. We have extensive experience in using ferrets for influenza studies as well.

Below is a basic study description and design, although IITRI can provide specialized study designs based on your needs. Contact us today to learn more and discuss how we can partner for SARS-CoV-2 animal studies.

 

Species Information

Ferrets

Study Duration Sponsor dependent (7-14+ typical)
Challenge Dosage and Strains

Intranasal (1×10^6 TCID50 of SARS-CoV-2); wildtype USA-WA1/2020),  B.1.1.7 ,  B.1.35P.1.

Drug administration

Aerosol, PO, IN, SC, IV (inquire about others)

 

Possible Endpoints

– General clinical observations

– Body Weight

– Viral load in nasal washes (TCID50 for live virus, SARS-CoV-2-specific RTqPCR)

– Tissue viral burden by TCID50 and/or RT-qPCR

– Histopathology of tissues, to be evaluated with standard H.E. staining

– Neutralizing antibody titer

– Cytokine expression by RT-qPCR (ELISA reagents for ferrets are very limited)