Service Spotlight : Vaccine Challenge and Toxicology Studies

August is National Immunization Awareness Month (NIAM) which serves as reminder of the importance of vaccination for people of all ages. We’re proud to play a role in the development and testing of vaccines here at IITRI. IITRI has decades of experience conducting vaccine efficacy, safety, and toxicity studies on a variety of vaccine types including inactivated live attenuated viral and bacterial preparations, plasmid DNA, nanoparticles, viral vector immunotherapies, and adjuvanted vaccines.

The race to develop vaccines and anti-infectives against emerging new pathogens (e.g., COVID-19, Zika, Ebola) and long-standing infectious diseases (e.g., influenza, tuberculosis) is accelerating due to innovations in vaccine technologies and therapeutic strategies. Yet, once the potential of a new vaccine or treatment is confirmed in vitro, researchers who are unfamiliar with the in vivo challenge and GLP toxicology studies required for IND submissions may be unclear on how to proceed. 

At IITRI, we have the expertise to walk you through the whole process successfully. Our comprehensive vaccine services include challenge studies in relevant animal models (rodent, non-rodent, NHP) for pathogens requiring BSL-2 and BSL-3 containment as well. GLP vaccine toxicology services include repeat-dose studies in rabbits, rodents and large animals (canine, ferret, and non-human primate/NHPs), biodistribution, and immunogenicity studies to meet FDA submission guidelines. We offer all dosing routes including inhalation and an array of supporting assays here at our on-site GLP compliant bioanalytical laboratory as well. 

Our team would love to speak to anyone looking to test their candidates, so feel free to contact us anytime.

Vaccine Toxicology Services